Description
Since the inception of lab-on-a-chip (LOC) and micro-total-analysis-systems (μTAS) concepts, a diverse array of microsystems founded on microfluidics has been introduced. Among these, centrifugal microfluidics emerges as particularly noteworthy, showcasing several distinctive advantages over alternative forms. Its most pronounced merit lies in its divergence from the necessity for intricate tubes or pumps in controlling solution flow, a departure from the complexities inherent in other microfluidic devices. This characteristic streamlines device design and fabrication, thereby amplifying data reproducibility through the elimination of manual interventions.
For several years, my research has focused on microdevices for genetic diagnostics grounded in various driving forces such as electrokinetic and hydrodynamic forces. The challenges encountered in establishing consistent conditions for the same chip, stemming from complications in creating tube connection part on a chip, managing multiple tubes for sample in-and-out, and addressing irregular pump operations, have prompted a search for more efficient solutions. In this context, centrifugal microfluidics has proven invaluable, effortlessly executing fundamental unit operations such as volume splitting, solution merging, passive valving, and flow switching solely through rotational force and direction. This capability, coupled with straightforward microfluidic design and surface treatment, underscores the practicality of centrifugal microfluidics.
Within our specialized genetic diagnostics research lab, centrifugal microfluidics was initially introduced for genomic extraction in 2008. Subsequent developments encompassed various forms of genetic diagnostic centrifugal microfluidics, including polymerase chain reaction, isothermal amplification, a lateral flow strip assay, and a solution-loading cartridge facilitating the entire process from sample loading to diagnosis. Additionally, our lab has expanded its focus to high-throughput immuno-diagnostics and nanoparticle synthesis using centrifugal microfluidics, culminating in a high-throughput concept capable of concurrently processing up to 40 samples in a single device, offering a distinct advantage over other microfluidic forms.
Collating our laboratory's published papers, I organized them into ten chapters. The central theme of this book revolves around two primary applications of centrifugal microfluidic technologies: genetic analysis and nanoparticle synthesis. These sections distinguish themselves through their depth and detail, providing a comprehensive examination of the processes from both theoretical and practical perspectives. Each chapter intricately dissects device design, operational principles, and the unparalleled efficiency of centrifugal microfluidics in molecular diagnostics and nanoparticle synthesis.
It is my hope that this work stimulates contemplation among readers regarding the potential impacts of these technologies across various sectors, particularly in the field of nanobiotechnology. With its resonance within both the scientific community and industry practitioners, the book can offer insights into how centrifugal microfluidics is shaping the future of rapid and accurate biomedical diagnostics, contributing significantly to global health strategies, as well as exploring novel smart nanomaterials for the future.
For several years, my research has focused on microdevices for genetic diagnostics grounded in various driving forces such as electrokinetic and hydrodynamic forces. The challenges encountered in establishing consistent conditions for the same chip, stemming from complications in creating tube connection part on a chip, managing multiple tubes for sample in-and-out, and addressing irregular pump operations, have prompted a search for more efficient solutions. In this context, centrifugal microfluidics has proven invaluable, effortlessly executing fundamental unit operations such as volume splitting, solution merging, passive valving, and flow switching solely through rotational force and direction. This capability, coupled with straightforward microfluidic design and surface treatment, underscores the practicality of centrifugal microfluidics.
Within our specialized genetic diagnostics research lab, centrifugal microfluidics was initially introduced for genomic extraction in 2008. Subsequent developments encompassed various forms of genetic diagnostic centrifugal microfluidics, including polymerase chain reaction, isothermal amplification, a lateral flow strip assay, and a solution-loading cartridge facilitating the entire process from sample loading to diagnosis. Additionally, our lab has expanded its focus to high-throughput immuno-diagnostics and nanoparticle synthesis using centrifugal microfluidics, culminating in a high-throughput concept capable of concurrently processing up to 40 samples in a single device, offering a distinct advantage over other microfluidic forms.
Collating our laboratory's published papers, I organized them into ten chapters. The central theme of this book revolves around two primary applications of centrifugal microfluidic technologies: genetic analysis and nanoparticle synthesis. These sections distinguish themselves through their depth and detail, providing a comprehensive examination of the processes from both theoretical and practical perspectives. Each chapter intricately dissects device design, operational principles, and the unparalleled efficiency of centrifugal microfluidics in molecular diagnostics and nanoparticle synthesis.
It is my hope that this work stimulates contemplation among readers regarding the potential impacts of these technologies across various sectors, particularly in the field of nanobiotechnology. With its resonance within both the scientific community and industry practitioners, the book can offer insights into how centrifugal microfluidics is shaping the future of rapid and accurate biomedical diagnostics, contributing significantly to global health strategies, as well as exploring novel smart nanomaterials for the future.
Centrifugal Microfluidics for Nanobiotechnology
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